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Nerve
Cells
The nervous system is the
body's information gatherer, storage center and control system. Its overall
functions are to collect information about the
body's external/internal states and transfer this information to the
brain (afferent system), to analyze this information, and to send
impulses out (efferent system) to initiate appropriate motor responses
to meet the body's needs.
The system is composed of
specialized cells, termed nerve cells or neurons, that communicate
with each other and with other cells in the body. A neuron has three
parts:
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the cell body, containing
the nucleus
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dendrites, hair-like
structures surrounding the cell body, which conduct incoming signals.
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the axon (or nerve
fiber), varying in length from a millimeter to a meter, which conduct
outgoing
signals emitted by the neuron. Axons are encased in a fat-like sheath,
called myelin, which acts like an insulator and, along with the
Nodes
of Ranvier, speeds impulse transmission.
Typically a given neuron is
connected to many thousands of neurons. The specific point of contact between
the axon of one cell and a dendrite of another is called a
synapse.
Messages passed to and from the brain take the form of electrical impulses,
or action potentials,
produced by a chemical change that progresses along the axon. At the synapse,
the impulse causes the release of neurotransmitters (like acetylcholine
or dopamine) and this, in turn, drives the impulse to the next neuron.
These impulses travel very fast along these chain of neurons -- up to 250
miles per hour. This contrasts with other systems, such as the endocrine
system, which may take many hours to respond with hormones.
The nerve cell bodies are generally
located in groups. Within the brain and spinal cord, the collections of
neurons are called nuclei and constitute the gray matter,
so-called because of their color. Outside the brain and spinal cord the
groups are called ganglia. The remaining areas of the nervous system
are tracts of axons, the white matter, so-called because of white
myelin sheath. Tracts carrying information of a specific type, such as
pain or vision, generally have specific names.
Somatosensory Receptors
Input (afferent system)
to the nervous system is in the form of our five senses: touch/pain, vision,
taste, smell, and hearing. Pain, temperature, and pressure are known as
somatic
senses. Sensory receptors are classified according to the type of energy
they can detect and respond to.
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Mechanoreceptors: hearing
and balance, stretching.
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Photoreceptors: light.
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Chemoreceptors: smell
and taste mainly, as well as internal sensors in the digestive and circulatory
systems.
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Thermoreceptors: changes
in temperature.
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Electroreceptors: detect
electrical currents in the surrounding environment.
Major Divisions of the Nervous System
The nerves of the body are
organized into two major systems:
The two systems function together,
with nerves from the periphery entering and becoming part of the central
nervous system, and vice versa.
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In the PNS, collections of neurons
are
called ganglia.
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In the CNS, collections of neurons
are called nuclei.
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Brain Structures
Cerebrum
The largest division of
the brain, the cerebrum, consists of two sides, the right and left cerebral
hemispheres, which are interconnected by the corpus callosum.
The two hemispheres are "twins," each with centers for receiving sensory
(afferent) information and for intiating motor (efferent)
responses. The left side sends and receives information to/from
the right side of the body, and vice versa. Various intellectual
functions are concentrated in either the left
or right hemispheres.
The hemispheres are covered
by a thin layer of gray matter known as the cerebral cortex. The
interior portion consists of white matter, tracts, and nuclei (gray matter)
where synapses occur. Each hemisphere of the cerebral cortex is divided
into four "lobes"
by various sulci and gyri: The sulci (or fissures) are the
grooves and the gyri are the "bumps" on the brain's surface.
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Web
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The four lobes perform
specific functions:
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frontal
- controls fine movements (Betz cells)/ upper motor neuron)
and smell. Also, center for abstract thinking, judgment, and language
(left hemisphere)
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parietal
- coordinates afferent infromation dealing with pain, temperature, form,
shape, texture, pressure, and position. Some memory functions are also
found here.
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temporal
- handles dreams, memory, and emotions. Center for auditory function.
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occipital
- governs vision
In addtion to the four lobes,
you find basal ganglia. The basal ganglia, actually aggregates of
neurons (gray matter), constitute the extrapyramidal system. The
extrapyramidal system governs postural adjustment and gross voluntary
movements, as opposed to fine movements, controlled by the frontal
lobe. The basal ganglia receive afferent input from the cerebral
cortex and thalamus. Their axons synapse in
the brain stem and the spinal cord.
Function summary:
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"Consciousness" - awareness
of one's self and one's environment
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Thought/ reasoning/ memory
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Vision, hearing, touch
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Speech, language
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Motor control (fine and gross)/
coordination
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Emotions ("limbic
system" or the "emotional brain")
Cerebellum
The cerebellum,
the second largest brain structure, sits below the cerebrum. Like the cerebrum,
the cerebellum has an outer cortex of gray matter and two hemispheres.
It receives/relays information via the brain stem.
The cerebellum performs 3 major functions, all of which have to do with
skeletal-muscle control:
Function summary:
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Balance/ Equilibrium of the
trunk (See also: Vestibular System)
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Muscle tension, spinal
nerve reflexes, posture and balance of the limbs
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Fine motor control, eye movement.
(Incoming information is transferred from the cerebral cortext via the
pons.
Outgoing information goes back to the cortex via the thalamus.)
Cerebellar disease (abscess,
hemorrhage, tumors, trauma) results in ataxia (muscle incordination),
tremors, and disturbances of gait and equilibrium. This can also interfere
with a person's ability to talk, eat, and perform other self care tasks.
Paralysis does not result from loss of cerebellar function.
Diencephalon
The diencephalon, located
between the cerebrum and the midbrain,
consists of several important structures, two of which are the:
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Thalamus: large, bilateral
(right thalamus/left thalamus) egg-shaped mass of gray matter serving as
the main synaptic relay center. Receives/relays sensory information to/from
the cerebral cortex, including pain/pleasure centers.
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Hypothalamus: a collection
of ganglia located below the thalamus and intimatetly associated with the
pituitary gland. It has a variety of functions: senses changes in body
temperature; controls autonomic
activites and hence regulates the sympathetic and parasympathetic nervous
systems; links to the endocrine
system/controls the pituitary
gland; regulates appetite; functions as part of the arousal or alerting
mechanism; and links the mind (emotions) to the body -- sometimes, unfortunately,
to the degree of producing "psychosomatic disease."
Function summary:
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Voluntary movement/ motor integration
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Perception/ Sensory/mind-body
integration
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Temperature
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Appetite
Brain Stem
The medulla
oblongata,
pons,
and midbrain
(mesencephalon or cerebral peduncles) -- often referred to
collectively as the brain stem -- control the most basic life functions.
Of these three, the medulla is the most important. In fact, so vital is
the medulla to survival that diseases or injuries affecting it often prove
fatal. All functions of the brain stem are associated with cranial
nerves III-XII.
Function summary:
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Breathing/respiration (pons,
medulla)
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Heart rate/ action (medulla)
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Blood pressure (vasoconstriction)/
blood vessel diameter (medulla)
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Reflex centers for pupillary
reflexes and eye movements (midbrain, pons); and for vomiting, coughing,
sneezing, swallowing, and hiccuping (medulla).
Blood supply
An intricate arterial
structure supplies the brain with oxygen-rich blood. At the brain stem,
two vertebral arteries, entering through the first cervical vertebrae,
join to form the basilar
artery. The basilar artery along with two internal
carotid arteries, entering through holes at the base of the skull,
interconnect at the Circle
of Willis. From there, the anterior
and middle cerebral
arteries arise; the posterior
cerebral artery arises from the basilar system.
Cranial Nerves
There are 12 pairs of cranial
nerves. Some bring information from the sense organs to the brain; some
control muscles; others are connected to glands or internal organs.
The nerves are often remembered
by the
mnemonic
...
"On Old Olympic Towering Top
A Famous Vocal German
Viewed Some Hops"
... standing for: Ofactory,
Optic,
Oculomotor,
Trochlear,
Trigeminal,
Abducens,
Facial,
Vestibulocochlear,
Glossopharyngeal,
Vagus,
Spinal
accessory, Hypoglossal.
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| Cranial
Nerve |
Major Functions |
| I
Olfactory |
smell |
| II
Optic |
vision |
| III
Oculomotor |
eyelid and eyeball movement |
| IV
Trochlear |
innervates superior oblique
turns eye downward and laterally |
| V
Trigeminal |
chewing
face & mouth touch &
pain |
| VI
Abducens |
turns eye laterally |
| VII
Facial |
controls most facial expressions
secretion of tears &
saliva
taste |
VIII
Vestibulocochlear
(auditory) |
hearing
equillibrium sensation |
| IX
Glossopharyngeal |
taste
senses carotid blood pressure |
| X
Vagus |
senses aortic blood pressure
slows heart rate
stimulates digestive organs
taste |
| XI
Spinal
Accessory |
controls trapezius &
sternocleidomastoid
controls swallowing movements |
| XII
Hypoglossal |
controls tongue movements |
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Spinal Cord
Motions
and Functions Available at Different Levels of Spinal Cord Injury
The
spinal
cord lies within the spinal cavity, consisting of the vertebral
column, the meninges, spinal nerves, spinal fluid, blood vessels, and
a cushion of adipose/fat tissue. The spinal cord has two general functions:
1) It provides the two-way conduction routes to/from (afferent/efferent)
the brain; and 2) it serves as the reflex center for all spinal reflexes.
Thirty-one pairs of nerves connect to the spinal cord. They have no special
names, but are numbered according to the level of the spinal column from
which they emerge. There are 8 cervical (C1-C8), 12 thoracic (T1-T12),
5 lumbar (L1-L5), 5 sacral (S1-S5), and 1 coccygeal pairs of spinal nerves.
The figure below shows a cross-section
of the spinal cord at a typical level, illustrating the position of the
horns,
where the nerves synapse, and the three main tracts:
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Spinothalamic tract,
carrying pain and temperature impulses to the thalamus and the parietal
lobe
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Posterior columns, carrying
position and pressure sense to the thalamus and the parietal lobe
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Corticospinal (or pyrimidal)
tract,
carrying impulses to initiate muscle activity from the frontal lobe.

Each nerve has two roots
connecting to the spinal cord: The posterior (dorsal) is the sensory root;
the anterior (ventral) is the motor root. Sensory
receptors send information to the spinal cord (and thus to the brain)
through the spinal nerve. The cell bodies for these nerve fibers are located
in the dorsal
root ganglion and enter the spinal cord through the
dorsal/posterior
root. Some fibers synapse with other neurons in the dorsal/posterior
horn, while others continue up to the brain. The cell bodies in the
ventral/anterior horn send axons through the ventral/anterior root
to muscles to control movement.
Reflexes
A reflex is an automatic,
i.e."involuntary," response of the body to some stimulus, e.g. pupil dilation,
to collect more light, at night. Reflexes have afferent (signals to
the CNS) and efferent (signals from the CNS) components and may
involve one nerve/synapse (monosynaptic reflex) or multiple synapses
(polysynaptic reflex). The simplest spinal reflex is the tendon
reflex, a monosynaptic reflex. When the tendon is tapped, the sensory receptor
in the muscle sends a signal to the spinal cord (afferent system),
where it enters through the dorsal/posterior root, then synapses with a
sensory nerve axon in the ventral/anterior horn. From there, the receiving
axon carries the impulse through the ventral/anterior root back to the
muscle (efferent system) whose tendon was tapped. The muscle jerks/
contracts.
Spinal/Peripheral Nerves
All cervial spinal
nerves control movement of the shoulder and arm muscles and receive all
sensory input from the skin, muscles, bones, and joints. After leaving
the vertebral canal, they merge to form peripheral nerves. The merger
of the spinal nerves in the neck region is called the brachial plexis.
Main Action of the Brachial Plexus
Nerves
Modified from: Joel DeLisa
and Walter C. Stolov, "Significant Body Systems," in: Handbook of Severe
Disability, edited by Walter C. Stolov and Michael R. Clowers. US Department
of Education, Rehabilitation Services Administration, 1981, p. 27.
| Peripheral Nerve |
Action |
| Axillary |
Flex and abduct shoulder |
| Musculocutaneous |
Flex elbow |
| Radial |
Extend elbow, wrist, and
fingers |
| Median |
Flex wrist and fingers |
| Ulnar |
Dexterity of fingers |
The thoracic spinal
nerves do not recombine into plexuses. The anterior roots control the muscles
of the abdomen and back; the posterior roots receive information from the
abdomen, skin, and muscles and joints of the chest and upper back. The
lumbar
and sacral nerves, like the cervical, do combine after leaving the
vertebral canal. This merger, occuring in the pelvis, is called the lumbosacral
plexus, which controls the movement of, and receives information from,
the lower extremities, bladder, and bowel.
Main Action of the Lumbosacral Plexus
Nerves
Modified from: Joel DeLisa
and Walter C. Stolov, "Significant Body Systems," in: Handbook of Severe
Disability, edited by Walter C. Stolov and Michael R. Clowers. US Department
of Education,
Rehabilitation Services
Administration, 1981, p. 28.
| Peripheral Nerve |
Action |
| Femoral |
Extend knee |
| Sciatic |
Flex knee |
| Tibial |
Flex ankle and toes |
| Peroneal |
Extend ankle and toes |
| Pudendal |
Anal and urethral sphincters
and erection |
To Learn More
Web
resources:
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Acknowledgments:
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Joel DeLisa and Walter C. Stolov,
"Significant Body Systems," in: Handbook of Severe Disability, edited
by Walter C. Stolov and Michael R. Clowers. US Department of Education,
Rehabilitation Services Administration, 1981, pages 19-30.
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Catherine Parker Anthony and
Gary A. Thibodeau, Textbook of Anatomy & Physiology. St. Louis:
Mosby, 1983, pages 328-346.
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Anatomy
Clipart (Designs4Free)
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Dennis Kunkel, Electron
Microscopy Gallery
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J. Crimando, Anatomy
and Physiology Tutorials (Maricopa)
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